Has a critical role in neuronal development，particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover，facilitating beta-catenin interaction with GSK3B，phosphorylation，ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB3. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
