Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide，a propeptide of 99 aa，and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B，L and H，cathepsin S shows a restricted tissue distribution，with highest levels in spleen，heart，and lung. In addition，evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment，and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.
应用类型
WB, IHC
免疫原
A synthesized peptide derived from human CTSS
来源宿主
提供的抗组织蛋白酶S抗体Anti-Cathepsin S Antibody产品，该来源宿主查看产品说明书。
