PTEN，a tumor suppressor，has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides，and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB，and thus influence cell survival signaling.
应用类型
WB, IHC
免疫原
A peptide corresponding to the C-terminus of human PTEN
