The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation，cytokinesis，protein localization to the centromere and kinetochore，correct microtubule-kinetochore attachment，and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma，astrocytoma，seminoma and carcinomas of the colon，prostate，endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
应用类型
WB, IHC
免疫原
A peptide corresponding to the C-terminus of human Aurora kinase B
来源宿主
提供的抗Aurora B兔单克隆抗体Anti-Aurora B Rabbit Monoclonal Antibody产品，该来源宿主查看产品说明书。
