Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin，regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.
应用类型
WB, IHC
免疫原
A peptide corresponding to the residues in human CD29 (Integrin beta-1).
来源宿主
提供的抗整合素B1兔单克隆抗体Anti-Integrin beta-1 Rabbit Monoclonal Antibody n 产品，该来源宿主查看产品说明书。
