This antibody recognizes proteins of 31-44 kDa，which are identified as Clathrin Light Chains (both A & B). Clathrin is composed of three heavy chains and three light chains，which associate non-covalently to form a triskelion structure. Clathrin light chain regulates the self-assembly of triskelions onto intracellular membranes. Clathrin light chain subunits (LCA and LCB) contribute to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis. LCA and LCB are encoded by two discrete genes. They share only 60% homology，and have certain features in common. Both LCA and LCB undergo alternative mRNA splicing，which results in the generation of tissue-specific isoforms.
应用类型
FC, IF, IHC
免疫原
Purified recombinant N-terminal fragment of human Clathrin Light Chain
