It recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71)，a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This mAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein，transferrin. This receptor is broadly distributed in carcinomas，sarcomas，leukemias，and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
应用类型
FC, IF, WB, IHC
免疫原
Recombinant human TFRC protein fragment (aa94-212) (exact sequence is proprietary)
