CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence，three extracellular “scavenger receptor cysteine-rich” (SRCR) domains，a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes，peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
