This mAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135 kDa isoform is the basic molecule，which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule，the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma，medulloblastomas，astrocytomas，neuroblastomas，and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
应用类型
FC, IF, IHC
免疫原
Membrane preparation of a small cell lung carcinoma
