Nerve Growth Factor Receptor (NGFR)，also known as p75，P-75NTR or CD271，is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed mainly in Schwann cells and neurons，as well as a number of other non-neuronal cell types，and functions during central and peripheral nervous system development to regulate neuronal growth，migration，differentiation，and cell death. Nerve Growth Factor Receptor is also expressed in melanocytes，melanomas，neuroblastomas，pheochromocytomas，neurofibromas，neurotized nevi (type C melanocytes)，and other neural crest cell or tumor derivatives. It has been suggested that NGFR may act as a tumor suppressor indicated in prostate and urothelial cancer，and Anti-Nerve Growth Factor Receptor (NGFR) is often used in adjunct with S100，to aid in the diagnosis of desmoplastic and neurotropic malignant melanomas. Anti-NGFR is also useful as an aid in the diagnosis of breast malignancy，as the antibody labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts.
