SRY (Sex Determining Region Y)-Box 10 (SOX-10)，also known as transcription factor SOX-10，is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas，and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional，spindled，and desmoplastic melanoma，and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
