CD45R，also designated CD45 and PTPRC，has been identified as a transmembrane glycoprotein，broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4，5，and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4)，CD45RB (exon 5)，CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R，while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemia’s of B-cell origin.
应用类型
FC, IF, IHC
免疫原
Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V)
来源宿主
提供的抗CD45RB抗体（克隆BRA-11（与BRA-11G相同））Anti-CD45RB Antibody (Clone BRA-11(same as BRA-11G))产品，该来源宿主查看产品说明书。
