Recognizes the γ-chain of CD3，which consists of five different polypeptide chains (designated as gamma，delta，epsilon，zeta，and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly，CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes，CD3 is predominantly intra-cytoplasmic. However，in medullary thymocytes，it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells，and is present in majority of T cell neoplasms.
