Cluster of differentiation 57 (CD57)，also known as NK-1，is an antigen detectable in natural killer cells，some T-lymphocytes and normal peripheral blood mononuclear cells，myeloid cells，and a variety of polypeptides，lipids，and chondroitin sulfate proteoglycans. CD57 is indicated as a marker for tumors of neuroendocrine origin，including pheochromocytomas，paragangliomas，carcinoid tumor，and medulloblastomas，as well as various neural tumors including neuromas，neurofibromas，schwannomas，and granular cell tumors. CD57 is also detectable in ganglioneuroma and prostate carcinoma. Anti-CD57 is used to distinguish nodular lymphocyte-predominant Hodgkin’s lymphoma from T-cell/histiocyte-rich large B-cell lymphoma，nodular sclerosis Hodgkin’s disease，and follicular lymphoma.
