The affinity purified mouse monoclonal antibody is immunospecific for the ZnF domain of human histone deacetylase 6 (HDAC6) as determined by ELISA and peptide library screening. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains，the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm，but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including -tubulin，HSP90，cortactin，histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility，apoptosis，cell signaling and transcriptional regulation，protein degradation，immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis
应用类型
ELISA, IC/IF, IP
免疫原
Human Histone deacetylase 6 (HDAC6; sequence NP_006035.2, UniProtKB - Q9UBN7)
