Recognizes a protein of a disulfide-linked 120kDa dimer，identified as CD27. It is expressed on the majority of peripheral T cells，medullary thymocytes，memory-type B cells，and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70，a member of the TNF family，and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NF-κB and SAPK/JNK and induces apoptosis.
应用类型
FC, IF, IHC
免疫原
Recombinant human CD27 protein (exact sequence is proprietary)
