CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-，E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such，this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications，tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans，for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
应用类型
FC, IF, IHC
免疫原
Recombinant human full-length SELPLG (CD162) protein
