Recognizes a protein of 145kDa，identified as CD11c. CD11c (ITGAX)，a member of the leukointegrin family，shares the same beta subunit with other members of the leukocyte adhesion molecule family，which includes CD11a (LFA-1)，CD11b (MAC-1) and CD11d (ITGAD)，but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis，cell migration，and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes，tissue macrophages，NK cells，and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
应用类型
FC, IF, IHC
免疫原
Recombinant human ITGAX protein fragment (aa 637-827)
