It recognizes a protein of 80-87kDa，identified as gamma-catenin. The catenins (，B，γ and δ) are ubiquitously expressed，cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin，also referred to as VR22，is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to B-catenin，and it functions to inhibit Wnt signaling. CTNNA3，the gene that encodes for -T-catenin，is located on chromosome 10，and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
应用类型
FC, IF, WB
免疫原
Recombinant full length human plakoglobin, fused to maltose binding protein
