This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability，and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors，DNA damage sensors，and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II，and through the C-terminal domain，also interacts with histone deacetylase complexes. This protein thus plays a role in transcription，DNA repair of double-stranded breaks，and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
应用类型
FC, IF, IHC
免疫原
Recombinant human BRCA1 protein fragment (aa445-620)
