BCL10，with an N-terminal caspase recruitment domain (CARD)，is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NFĪŗB activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation，while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern，although at a much lower level.
应用类型
FC, IF, IHC, WB
免疫原
Human BCL10 recombinant protein (epitope aa122-168)
