Recognizes a protein of 39 kDa，which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation，cytokinesis，protein localization to the centromere and kinetochore，correct microtubule-kinetochore attachment，and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma，astrocytoma，seminoma and carcinomas of the colon，prostate，endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
应用类型
FC, IF, WB
免疫原
Recombinant human Aurora B protein fragment (aa 89-251)
来源宿主
提供的抗Aurora B抗体（AURKB/1521）Anti-Aurora B Antibody (AURKB/1521)产品，该来源宿主查看产品说明书。
