Recognizes a protein of 35-38kDa，which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes which differ in subcellular localization，regulation，and possibly function. Arginase I is a cytosolic enzyme，which is expressed mainly in the liver as part of the urea cycle，whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
应用类型
FC, IF, IHC, WB
免疫原
Recombinant fragment (87 Amino acid residues around aa 1-150) of human ARG1 protein
