D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to -ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites，D2HG and L-2-hydroxyglutarate (L2HG)，during biomarker assays.
应用类型
Western blot
免疫原
Full-length D2HGDH from Acidaminococcus fermentans
