Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes，maturation of spliceosomal snRNPs，apoptosis，DNA repair，tumor necrosis factor (TNF)-alpha signaling，activation of c-Jun N-terminal kinase MAPK8，regulation of histone acetylation，DNA damage checkpoint signaling，NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.
应用类型
WB, IF
免疫原
Recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli
