Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos，microtubules and dynein. Essential for targeting dynein to microtubule plus ends，recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule.
应用类型
WB
免疫原
Recombinant human DCTN1 protein fragments expressed in E.coli
