PRMT6 is a protein arginine N-methyltransferase，and catalyzes the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation is a prevalent post-translational modification in eukaryotic cells that has been implicated in signal transduction，the metabolism of nascent pre-RNA，and the transcriptional activation processes. IPRMT6 is functionally distinct from two previously characterized type I enzymes，PRMT1 and PRMT4. In addition，PRMT6 displays automethylation activity; it is the first PRMT to do so. PRMT6 has been shown to act as a restriction factor for HIV replication.
应用类型
WB, IF, IHC
免疫原
Recombinant human PRMT6 protein fragments expressed in E.coli
