Histone demethylase that specifically demethylates 'Lys-4' of histone H3，thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9'，H3 'Lys-27'，H3 'Lys-36'，H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2
应用类型
WB, IF
免疫原
Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli
