HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway，the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction，HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis，it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver，which lowers plasma concentration of cholesterol.
应用类型
WB
免疫原
GST Tagged recombinant human HMG-CoA Reductase Catalytic Domain (aa 426–888)
来源宿主
提供的抗HMG CoA还原酶抗体Anti-HMG CoA Reductase Antibody产品，该来源宿主查看产品说明书。
