Sphingosine 1-Phosphate Receptor 1 (S1P1) is a multi-pass cell membrane protein that belongs to the Gprotein coupled receptor superfamily (GPCR). S1P1 is a receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Clinical significance of S1P1 encompasses various diseases including cancer and multiple sclerosis. S1P1 seems to be coupled to the G(i/o) subclass of heteromeric G proteins
应用类型
ELISA, IP, IF, WB, FACS
免疫原
Modified 5-hydroxymethylcytosine found in DNA vertebrates
