5-methylcytosine (5-mC) is a modified base present in nucleic acids of plants and vertebrates. DNA methylation is a post-replicative process involved in the establishment of genomic imprinting，in the control of gene expression and of differentiation. Carcinogenesis is associated with alterations of the DNA methylation pattern: a global hypomethylation is often detected in tumor tissues when compared to their normal counterpart. Simultaneously local hypermethylation sites are observed.
应用类型
WB, ELISA, MeDIP/ChIP, IF, , IHC, FC
免疫原
Modified ribonucleoside, specific for the presence of a methyl group on carbon 5 of the pyrimidine ring
