Binds to TEK/TIE2，competing for the ANGPT1 binding site，and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers，such as VEGF，ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF，it may facilitate endothelial cell migration and proliferation，thus serving as a permissive angiogenic signal.
应用类型
WB
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Angiopoietin-2
