Non-catalytic subunit of AMP-activated protein kinase (AMPK)，an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels，AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein，carbohydrate and lipid biosynthesis，as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes，and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles，via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1，PRKAG2 or PRKAG3).
应用类型
WB, ELISA, IHC
免疫原
Synthesized peptide derived from human AMPKB1 around the phosphorylation site of S182.
