Catalytic subunit of AMP-activated protein kinase (AMPK)，an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels，AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein，carbohydrate and lipid biosynthesis，as well as cell growth and proliferation. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2，RPTOR and ATG1/ULK1: in response to nutrient limitation，negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
应用类型
WB, ELISA, IHC
免疫原
Synthesized peptide derived from human AMPK1 around the phosphorylation site of S496 (420-500aa)
