ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK，MKK4 and MKK6，which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas through the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However，a catalytically inactive form of ASK1 has been shown to inhibit TNF- induced apoptosis.
应用类型
WB, ELISA, IHC
免疫原
Synthesized peptide derived from human ASK 1 around the phosphorylation site of S83, (20-100aa)
