LILRB5 is a member of the leukocyte immunoglobulin-like receptor (LIR) family，which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains，a transmembrane domain，and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.
应用类型
WB, IH
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human LILRB5
