Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development，function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR)，a series of phosphorylation lead to the recruitment of TXK to the cell membrane，where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways，including regulation of the actin cytoskeleton. Like ITK，can phosphorylate PLCG1，leading to its localization in lipid rafts and activation，followed by subsequent cleavage of its substrates.
应用类型
WB, IH
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TXK
