E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86，and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6
应用类型
WB, IH, IF/IC
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MARCH2
