Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A,GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where,in cooperation with the BECN1-PI3-kinase class III complex,they trigger autophagosome development. Acts as a transcriptional activator of THRA.
应用类型
WB, IH, IF/IC
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TP53INP2