Component of the anaphase promoting complex/cyclosome (APC/C)，a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and，to a lower extent，the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
应用类型
WB, IH, IF/IC
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ANAPC1
