Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin，limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation，DNA repair，DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones，also called histone code，and nucleosome remodeling.
应用类型
WB, ICC, ELISA, Multiplex
免疫原
A peptide corresponding to the C-terminus of human Histone H2A
