Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin，limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation，DNA repair，DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones，also called histone code，and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
应用类型
WB, ICC, ELISA, Multiplex
免疫原
A peptide corresponding to the C-terminus of human Histone H2AX
