p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cellular responses to cytokines and stress. Like the SAPK/JNK pathway,p38 MAP kinase is activated by a variety of cellular stresses including inflammatory cytokines,UV light and growth factors,etc. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.
应用类型
IHC, WB
免疫原
A phospho-peptide corresponding to human Phospho-p38 MAPK (Thr180/Tyr182)