Human rhinovirus (HRV) infections are the most frequent causative agents of common cold and various other upper respiratory tract infections. Rhinoviruses are members of the picornavirus family，which have a positive-sense，single-stranded RNA genome that is translated into a single polyprotein precursor. In the case of HRVs，the viral polyprotein is mainly processed by the proteases (2A and 3C) to generate functional proteins and enzymes.
