- 中文名称
Apoptosis (Mouse) BioAssay Sample Kit
- 英文名字
- Apoptosis (Mouse) BioAssay Sample Kit
- 供应商
- USBiological
- 产品货号
- A1059-89A
- 产品报价
- ￥1/8x20ul
- 产品说明书
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- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- The Apoptosis Antibody Sampler Kit (Mouse Specific) is designed for use with mouse samples and offers an economical way of testing for apoptosis. The kit contains 20ul of each primary antibody and 100ul of Anti-rabbit IgG, HRP-linked Antibody. Apoptosis, or programmed cell death, is a regulated physiological process leading to cell death. Caspases, a family of cysteine acid proteases, are central regulators of apoptosis. Initiator caspases (including 8, 9, 10 and 12) are closely coupled to proapoptotic signals. Once activated, these caspases cleave and activate downstream effector caspases (including 3, 6 and 7), which in turn cleave cytoskeletal and nuclear proteins like PARP, alpha-Fodrin, DFF and Lamin A, and induce apoptosis. Cytochrome c released from mitochondria is coupled to the activation of caspase-9, a key initiator caspase. Proapoptotic stimuli include the FasL, TNF-alpha, DNA damage and ER stress. Fas and TNFR activate caspases 8 and 10; DNA damage leads to the activation of caspase-9; and ER stress leads to the calcium-mediated activation of caspase-12. The inhibitor of apoptosis protein (IAP) family includes XIAP and Survivin and functions by binding and inhibiting several caspases (4,5). Smac/Diablo, a mitochondrial protein, is released into the cytosol upon mitochondrial stress and competes with caspases for binding of IAPs. The interaction of Smac/Diablo with IAPs relieves the inhibitory effects of the IAPs on caspases (6).1 Kit (8 x 20ul)Kit Components:1. IgG(HRP)Gt x Rb 1x100ul2. Caspase-3 Pab Rb x 1x20ul 3. Cleaved Caspase-3 (Asp175) Pab Rb x 1x20ul4. Cleaved Caspase-6 (Asp162) Pab Rb x 1x20ul5. Caspase-6 Pab Rb x 1x20ul6. Cleaved PARP (Asp214) RbxMo 1x20ul7. Caspase-12 Pab Rb x 1x20ul8. Caspase-9 Pab Rb x Mo 1x20ul9. Cleaved Caspase-9 (Asp353) Pab Rb x Mo 1x20ulEach antibody in the kit detects endogenous levels of its respective protein. Cleaved Caspase-3 (Asp175) antibody and Cleaved Caspase-6 (Asp162) antibody detect the large fragment of their respective proteins. Caspase-3 antibody and Caspase-9 antibody (Mouse Specific) detect the full length and the large fragments. Cleaved caspase-9 (Asp353) detects the cleaved large 37 kD fragment. Caspase-6 antibody detects the full length fragment and the small subunit. Caspase-12 antibody detects the full length fragment and its cleaved product. Cleaved PARP (Asp214) antibody (Mouse Specific) detects the large fragment of mouse PARP produced by caspase cleavage.Polyclonal antibodies are produced by immunizing rabbits with synthetic peptides (KLH coupled) corresponding to amino-terminal residues of proteolytic cleavage sites of cleaved caspase-3 (Asp175), cleaved caspase-6 (rat Asp162), cleaved caspase-9 (Asp353), mouse-cleaved PARP, and residues surrounding amino acid 158 of mouse caspase-12. Antibodies are purified by protein A and peptide affinity chromatography.
- 产品特点
- 针对Apoptosis (Mouse) BioAssay Sample Kit该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Apoptosis (Mouse) BioAssay Sample Kit产品后将其置于-20°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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