Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors，the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein，an adenylyl cyclase，cAMP-dependent kinase，and the counterbalancing phosphatase，PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
应用类型
Western blot, IHC
免疫原
KLH conjugated synthetic peptide between 236-264 amino acids from human BAR2
