Aldo-keto reductase family 1 member C3 in humans is encoded by the AKR1C3 gene. This enzyme catalyzes the reduction of prostaglandin (PG) D2，PGH2 and phenanthrenequinone (PQ)，and the oxidation of 9alpha，11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma，and may also have a role in controlling cell growth and/or differentiation.
