Bevacizumab (Avastin) is a recombinant humanized monoclonal IgG1 antibody. Bevacizumab，targets the cell surface protein called vascular endothelial growth factor (VEGF) results in suppression of tumor growth. VEGF plays an essential role in developmental angiogenesis and is also important for reproductive and bone angiogenesis. Avastin is used to treat various cancers like metastatic colorectal cancer，non-squamous non–small cell lung cancer，metastatic breast cancer，glioblastoma and metastatic renal cell carcinoma.
