- 中文名称
FBXO11抗体(N端)
- 英文名字
- FBXO11 Antibody (N-term)
- 供应商
- Abgent
- 产品货号
- A-AW5592
- 产品报价
- ￥3250/200 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- This gene encodes a member of the F-box protein family
which is characterized by an approximately 40 amino acid motif, the
F-box. The F-box proteins constitute one of the four subunits of
ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
which function in phosphorylation-dependent ubiquitination. The
F-box proteins are divided into 3 classes: Fbws containing WD-40
domains, Fbls containing leucine-rich repeats, and Fbxs containing
either different protein-protein interaction modules or no
recognizable motifs. The protein encoded by this gene belongs to
the Fbxs class. It can function as an arginine methyltransferase
that symmetrically dimethylates arginine residues, and it acts as
an adaptor protein to mediate the neddylation of p53, which leads
to the suppression of p53 function. This gene is known to be
down-regulated in melanocytes from patients with vitiligo, a skin
disorder that results in depigmentation. Polymorphisms in this gene
are associated with chronic otitis media with effusion and
recurrent otitis media (COME/ROM), a hearing loss disorder, and the
knockout of the homologous mouse gene results in the deaf mouse
mutant Jeff (Jf), a single gene model of otitis media.
Alternatively spliced transcript variants encoding distinct
isoforms have been identified for this gene.
- 应用类型
- WB
- 免疫原
- Q86XK2
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
