Dihydropyrimidinase catalyzes the conversion of
5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism.
Dihydropyrimidinase is expressed at a high level in liver and
kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript.
Defects in the DPYS gene are linked to dihydropyrimidinuria.
